About Me

Dr. Creamer is a basic research scientist with experience in in-vivo and in-vitro modeling of various cellular mechanisms involved in signaling pathways, and the downstream changes in gene expression in response to those signals in both normal and disease states. In particular, he has an interest in investigating the roll of various signaling networks, including nuclear receptors, and their effects on the transformation, proliferation, survival, and development of drug resistance in models of human breast cancer. Dr. Creamer has investigated the role of the Janus Kinase (JAK) and Signal Transducer and Activator of Transcription (STAT5) pathway in mammary epithelial cell survival as well as identified a novel splice variant of protein kinase B (AKT1) present only in the human mammary gland that leads to increased cell survival in both normal and neoplastic cells. By identifying networks which are dysregulated leading to enhanced cell survival, Dr. Creamer hopes to identify potential targets for therapy for use in breast cancer treatment. His work involves the use of advanced genetic and genomic methods including molecular cloning, in-vitro modeling, quantitative PCR, genomic sequencing including RNAseq, proteomics, and others.